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Why does standing increase hypertrophic cardiomyopathy murmur?

Most murmurs diminish in intensity with standing due to reduced venous return to the heart and subsequently reduced right and left ventricular diastolic volumes. In contrast, the murmur of hypertrophic cardiomyopathy becomes louder, and the murmur of mitral valve prolapse lengthens and often is intensified.

What causes murmur in HOCM?

The murmur of HOCM becomes quite loud with Valsalva maneuver. This maneuver effectively acts to decrease left ventricular filling, which results in worsened left ventricular outflow tract obstruction in patients with HOCM, making the murmur louder.

Why does hypertrophic cardiomyopathy have a systolic murmur?

Two murmurs are often cited as being present in patients with HCM. The first murmur is because of systolic anterior motion (SAM) of the mitral valve leading to poor leaflet coaptation and mitral regurgitation (Fig. 2B and C).

Why does HOCM murmur increase with Valsalva?

The murmur of HOCM becomes quite loud with Valsalva. By decreasing left ventricular filling, the left ventricular outflow tract obstruction worsens, making the murmur louder.

Does HOCM murmur increase on standing?

The murmur that is pathognomonic for HCM is a crescendo-decrescendo holosystolic murmur best heard at the left sternal boarder. The murmur classically increases with standing and valsalva, while it decreases with squatting, hand-grip, and passive leg lift.

Which murmur increases on standing?

Sudden standing increases the intensity of murmurs in hypertrophic obstructive cardiomyopathy and mitral valve prolapse. It decreases the strength of aortic stenosis, mitral stenosis, aortic regurgitation, mitral regurgitation, and ventricular septal defects. Amyl nitrate: Decreases afterload.

Why are ACE inhibitors contraindicated in HOCM?

Agents to reduce pre- or afterload (such as nitrate, ACE inhibitors, nifedipine-type calcium antagonists) are contraindicated with HOCM due to possible aggravation of the outflow tract obstruction. This often impedes therapy of coexistent arterial hypertension.

Where is HOCM best heard?

The murmur of HOCM is a medium-pitched ejection murmur best heard at the left sternal border.

What is the difference between HOCM and HCM?

This type of hypertrophic cardiomyopathy may be called hypertrophic obstructive cardiomyopathy (HOCM). HCM also may cause thickening in other parts of the heart muscle, such as the bottom of the heart called the apex, right ventricle, or throughout the entire left ventricle.

What is HOCM of the heart?

Hypertrophic Obstructive Cardiomyopathy (HOCM) is a cardiac abnormality which leads to the muscle in the wall of the heart growing and thickening to the point that it blocks blood flow exiting the heart.

What does HOCM stand for?

What does Hocm stand for?

Why is the HOCM murmur louder when standing?

HOCM murmur becomes louder on the Valsalva maneuver. This maneuver reduces left ventricular filling resulting in reduced left ventricular outflow and thus, a decrease in preload making the murmur quiet louder. The same effect is observed when standing from the sitting posture.

How does handgrip affect murmur intensity in HOCM?

Certain maneuvers can affect murmurs auscultated in HOCM. Handgrip will increase ventricular volume decreasing LV outflow gradient and decrease murmur intensity. Valsalva maneuver will decrease ventricular volume increasing LV outflow gradient and increase murmur intensity.

Why does the murmur of hypertrophic cardiomyopathy decrease with rapid squatting?

Why does the murmur of hypertrophic cardiomyopathy decrease with rapid squatting and hand grip? The murmur of hypertrophic cardiomyopathy (HOCM) is caused by turbulent flow in the left ventricular outflow tract (LVOT), which is the part of the heart just underneath the aortic valve.

Can a hypertensive cardiomyopathy cause a systolic murmur?

In addition, hypertensive cardiomyopathy cannot explain the patient’s systolic murmur that increases in intensity with a Valsalva maneuver. Restrictive cardiomyopathy could explain left ventricular hypertrophy.