What is trimetazidine 35mg used for?
Trimetazidine (35 mg twice daily) added to beta-blockade (atenolol) improved effort-induced myocardial ischemia, as reviewed by the European Medicines Agency (EMA) in June 2012 [123], and remains contraindicated in Parkinson’s disease and motion disorders (such as tremor (shaking), muscle rigidity and walking disorders …
Is trimetazidine safe for kidney?
Trimetazidine is contraindicated in patients with severe renal impairment. For patients with moderate renal impairment and the elderly, the dose should be reduced.
What does trimetazidine do to the body?
It is used to prevent and treat the symptoms of angina (chest pain). Angina is caused by lack of blood supply and oxygen to your heart. Trimetazidine helps to maintain the energy metabolism of heart muscle cells, protecting them from the effects of reduced oxygen supply.
How long should trimetazidine be taken?
In conclusion, treatment with trimetazidine added to the usual treatment for up to 18 months was well tolerated and induced functional improvement in patients with ischaemic dilated cardiomyopathy. Trimetazidine treatment was associated with a significant improvement of LV function and the remodelling process.
Is trimetazidine safe?
Trimetazidine has been generally very well tolerated in clinical trials and usually only isolated cases of adverse events (ADRs—adverse drug reactions) were observed during trimetazidine treatment (mainly gastrointestinal disturbances, vomiting, nausea) [61].
Is trimetazidine good?
TRIMETAZIDINE IN CORONARY INTERVENTIONS Summarily, trimetazidine showed an improvement in several ischemic parameters, such as reduction in the frequency of angina pectoris attacks and myocardial damage during PCI and CABG. It also improved left ventricular function during follow-up after percutaneous angioplasty.
What is the meaning of trimetazidine?
Trimetazidine is an anti-ischemic (anti-anginal) metabolic agent of the fatty acid oxidation inhibitor class, meaning that it improves myocardial glucose utilization through inhibition of fatty acid metabolism.
Is trimetazidine good for the heart?
Previous studies have shown that trimetazidine improves cardiac function by improving hemodynamics; however, the protective effect of trimetazidine on ischemic heart failure is not entirely due to its effects on the hemodynamic system.
What happens if you stop taking trimetazidine?
Discontinuing trimetazidine treatment in people with Parkinson’s disease may lessen their motor and non-motor symptoms and improve their quality of life, a study has found.
Can trimetazidine lower BP?
Effect of trimetazidine treatment on blood pressure & pulse rate. During 6 months of treatment with trimetazidine, clinically minor, but statistically significant reductions in systolic and diastolic blood pressure, and pulse rate were demonstrated compared with baseline values (p < 0.05; Table 2).
Does trimetazidine lower heart rate?
The dose of trimetazidine does not affect hemodynamic stability, heart rate, blood pressure and speed-pressure multiplication, and it exerts no negative inotropic effect.
Can you stop taking trimetazidine?
If you stop taking Trimetazidine 35 mg Do not stop taking your medicine without consulting your doctor. If you have any further questions on the use of this product, ask your doctor or pharmacist.
What is the C Max of trimetazidine 35 mg?
In elderly patients, a 35 mg oral modified release tablet reaches a mean C max of 115 µg/L, with a T max of 2.0-5.0 hours, and a mean AUC 0-12 of 1104 h*µg/L. 3 In young, healthy patients, the same dose reaches a mean C max of 91.2 µg/L, with a T max of 2.0-6.0 hours, and an AUC 0-12h 720 h*µg/L. 3
What kind of moiety does trimetazidine have?
Description This compound belongs to the class of organic compounds known as phenylmethylamines. These are compounds containing a phenylmethtylamine moiety, which consists of a phenyl group substituted by an methanamine.
When is the best time to take trimetazidine?
Elderly patients. Elderly patients may have increased trimetazidine exposure due to agerelated decrease in renal – function (see section 5.2). In patients with moderate renal impairment (creatinine clearance [3060] – ml/min), the recommended dose is 1 tablet of 35mg in the morning during breakfast.
When to use trimetazidine for angina pectoris?
Trimetazidine should only be used in the symptomatic treatment of angina pectoris, and only as add-on to existing treatments in patients who are not adequately controlled by or who are intolerant to other medicines for angina pectoris.