What is glycated albumin?
The glycated albumin (GA) is a test that reflects short-term glycemia and is not influenced by situations that falsely alter A1C levels. GA is the higher glycated portion of fructosamine. It is measured by a standardized enzymatic methodology, easy and fast to perform.
How does albumin work?
Albumin is a protein that is produced in the liver and then enters the bloodstream where it is carried to other parts of the body. Albumin’s biological functions are to keep fluid from leaking out of the blood and to carry substances like hormones, enzymes, and vitamins in the body.
What is glycated hemoglobin?
Glycosylated hemoglobin: Hemoglobin to which glucose is bound. Glycosylated hemoglobin is tested to monitor the long-term control of diabetes mellitus. The level of glycosylated hemoglobin is increased in the red blood cells of persons with poorly controlled diabetes mellitus.
What if albumin is high in urine?
Albuminuria is a sign of kidney disease and means that you have too much albumin in your urine. Albumin is a protein found in the blood. A healthy kidney doesn’t let albumin pass from the blood into the urine. A damaged kidney lets some albumin pass into the urine.
How is glycation of serum albumin related to diabetes?
In fact, serum albumin may undergo structural changes by glycation which impacts on its function and plays a major role in the genesis of diabetes mellitus complications. GA can be measured accurately either on serum or plasma collected on tubes containing lithium heparin or EDTA as anticoagulant.
Which is the best way to measure albuminemia?
Albuminemia can be measured by colorimetry using bromocresol green or bromocresol purple. Finally, GA is expressed as a percentage of total albumin. Analytical performances of the enzymatic assay including sensitivity, specificity, reproducibility, linearity and interferences are good .
When to use glycated hemoglobin or HBA 1C?
Glycated hemoglobin (HbA 1c) is the reference test for long-term glucose monitoring. However, HbA 1c is not recommended in several situations such as hemoglobinopathies, pregnancy or chronic kidney disease.