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What is flutamide used to treat?

Flutamide is used to treat prostate cancer. Flutamide is given in combination with another medicine called a luteinizing (LOO-tee-in-ize-ing) hormone-releasing hormone, or LHRH. LHRH helps prevent the testicles from producing testosterone. Flutamide may also be used for purposes not listed in this medication guide.

What is flutamide 125 mg used for?

This medication is used to treat men with prostate cancer. Flutamide belongs to a class of drugs known as anti-androgens (anti-testosterone). Testosterone, a natural hormone, helps prostate cancer to grow and spread.

What is flutamide mechanism of action?

Flutamide acts as a selective antagonist of the androgen receptor (AR), competing with androgens like testosterone and dihydrotestosterone (DHT) for binding to ARs in tissues like the prostate gland. By doing so, it prevents their effects and stops them from stimulating prostate cancer cells to grow.

Is flutamide a chemotherapy?

Phase II study of flutamide as second line chemotherapy in patients with advanced pancreatic cancer. Invest New Drugs.

What is generic for flutamide?

Generic name: Flutamide Eulexin is the trade name for Flutamide. In some cases, health care professionals may use the trade name Eulexin when referring to the generic drug name Flutamide. Drug type: Eulexin is a hormone therapy.

Does flutamide block testosterone?

Flutamide blocks testosterone from reaching the cancer cells. Without testosterone, the prostate cancer may shrink or stop growing.

Is flutamide the same as finasteride?

Conclusions: Both drugs are effective in the treatment of hirsutism but flutamide is more effective than finasteride.

What are the side effects of flutamide?

Flutamide may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • diarrhea.
  • nausea.
  • vomiting.
  • loss of appetite.
  • hot flashes.
  • decrease in sexual ability or desire.
  • breast enlargement in men.
  • drowsiness.

Does flutamide increase testosterone levels?

Flutamide is a nonsteroidal antiandrogen that blocks androgen receptors, with a consequent increase in serum immunoreactive LH (I-LH) in the presence of high testosterone concentrations.

What are the side effects of the drug flutamide?

How does flutamide help with PCOS?

The present results show that besides blocking androgen receptors, flutamide also induces a significant reduction in plasma androgen levels by inhibiting the atretic effect of LH on thecal and granulosa cells. They imply that high intraovarian levels of androgens are a major pathogenetic factor in PCOS.

How much flutamide to take for prostate cancer?

Flutamide Dosage 1 Usual Adult Dose for Prostate Cancer. For use in locally confined stage B2-C… 2 Usual Adult Dose for Hirsutism. Data has been reported in which 250 mg of flutamide 2… 3 Renal Dose Adjustments. 4 Liver Dose Adjustments. 5 Dose Adjustments. Consider dosage reduction in patients with liver disease based on desired clinical…

Can a Fexinidazole increase the dose of flutamide?

Adjust dose of drugs that are CYP3A4 substrates as necessary. fexinidazole will increase the level or effect of flutamide by affecting hepatic enzyme CYP1A2 metabolism. Use Caution/Monitor.

How often should you take flutamide for diarrhea?

Flutamide is usually taken every 8 hours. Follow your doctor’s dosing instructions very carefully. Drink plenty of liquids. Your doctor may recommend a special diet to help prevent diarrhea. You will need frequent medical tests.

Are there any side effects to taking flutamide after warfarin?

Use Caution/Monitor. Increases in prothrombin time have been noted in patients receiving long-term warfarin therapy after flutamide was initiated. Close monitoring of prothrombin time is recommended. atazanavir will increase the level or effect of flutamide by affecting hepatic/intestinal enzyme CYP3A4 metabolism.