What is EPO pathway?
EPO-induced intracellular signaling pathways Erythropoietin and its receptor signaling through JAK2 activate multiple downstream signaling molecules including STAT5, PI3K/Akt, NF-κB, and MAPK. These factors may play an important role in inflammation and neuroprogression in the nervous system.
What does the EPO receptor do?
EPO receptors are expressed on erythroid progenitor cells and the binding of EPO to its receptor results in the activation of JAK2 tyrosine kinase, which causes tyrosine phosphorylation in a number of proteins and triggers the activation of several signal transduction pathways involved in proliferation and in the …
What signals EPO?
The hormone erythropoietin (Epo) stimulates differentiation of bone-marrow erythroblasts into red cells by activating a binary intracellular Stat5 signal. The Epo signaling cascade begins when the hormone binds to the Epo receptor.
What receptor does EPO use?
The erythropoietin receptor (EpoR) is present on erythroid progenitor cells. When EPO binds to EpoR, apoptosis is inhibited through an intracellular signaling cascade producing increased numbers of RBCs. EpoR-modulated gene transcription is regulated by SHP1 binding.
What EPO means?
Exclusive Provider Organization
An EPO, or Exclusive Provider Organization, is a type of health plan that offers a local network of doctors and hospitals for you to choose from. If you’re looking for lower monthly premiums and are willing to pay a higher deductible when you need health care, you may want to consider an EPO plan.
Where are EPO receptors?
In the erythropoietic process, EPO induces homodimerization of the EPO receptor, which is located on the surface of erythroid progenitor cells. Dimerization activates the receptor-associated Janus kinase 2 via transphosphorylation.
What does EPO bind to?
Secreted EPO (165 amino acids) binds to EPO receptors on the surface of bone marrow erythroid precursors, resulting in their rapid replication and maturation to functional red blood cells. This stimulation results in a rapid rise in erythrocyte counts and a consequent rise in blood oxygen.
How does EPO work?
EPO is a peptide hormone that is produced naturally by the human body. EPO is released from the kidneys and acts on the bone marrow to stimulate red blood cell production. An increase in red blood cells improves the amount of oxygen that the blood can carry to the body’s muscles.
What does EPO stand for electrical?
Emergency Power Off (EPO) functionality enables an uninterruptible power supply and other related equipment such as generators to be remotely shut down in the event of a fire or building evacuation.
What does EPO stand for in construction?
The Emergency Power Off (EPO) button, also called an EPO switch or EPO panel, is a safety measure for quickly disconnecting electrical power to a particular piece of equipment, or to an entire facility, in the event of an emergency.
Is EPO a cytokine?
Erythropoietin is a cytoprotective cytokine induced by the hypoxia inducible factor family. EPO is the hematopoietic factor responsible for the production of red blood cells and for this function is produced mainly by the adult kidney.
What happens when EPO binds to the erythropoietin receptor?
Erythropoietin Receptor. The erythropoietin receptor (EpoR) is present on erythroid progenitor cells. When EPO binds to EpoR, apoptosis is inhibited through an intracellular signaling cascade producing increased numbers of RBCs.
Where does EPO-r signaling take place in the body?
Epo receptor (Epo-R) mutations. Epo-R signaling is regulated by the binding of the protein tyrosine phosphatase SHP-1 (or other JAK/STAT regulators) to the distal cytoplasmic region of Epo-R.
What is the function of the murine EPO receptor?
Murine Epo Receptor truncations and known functions. Erythroid differentiation depends on transcriptional regulator GATA1. EpoR is thought to contribute to differentiation via multiple signaling pathways including the STAT5 pathway. In erythropoiesis, EpoR is best known for inducing survival of progenitors.
How is the Epo / EpoR pathway involved in cell growth?
Our results suggested that Epo/EpoR pathway was involved in cell growth, invasion, survival, and sensitivity to the multi-kinases inhibitor Sunitinib in RCC cells.