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What is a spiradenoma?

A spiradenoma is an uncommon benign tumor arising from the eccrine sweat apparatus and is one of nine painful skin tumors, the others being leiomyoma, neuroma, dermatofibroma, angiolipoma, neurilemmoma, endometrioma, glomus tumor and granular cell tumor [1].

What is eccrine spiradenoma?

Eccrine spiradenoma is an uncommon benign tumor of skin adnexa originating from eccrine glands, which was first described by Kersting and Helwig [1]. It is usually appeared as a single nodule, but also appears rarely as multiple nodules, and being distributed as a linear form or zosteriform [2].

What is nodular Hidradenoma?

Nodular hidradenoma (NH) is a benign adnexal tumor that arises from either eccrine or apocrine sweat glands. NH can originate from any cutaneous site, but the most common sites are the head and anterior surface of the trunk, with very rare cases in the extremities.

Is eccrine Spiradenoma cancerous?

Background: Eccrine spiradenoma is a well-differentiated benign tumor of the sweat glands. Malignant change arising within eccrine spiradenoma is rare.

How do you get Brooke Spiegler syndrome?

Brooke-Spiegler syndrome, familial cylindromatosis and multiple familial trichoepitheliomas are due to germline mutations in the cylindromatosis (CYLD) gene on chromosome 16q12. These disorders have an autosomal dominant inheritance, meaning half of an affected individual’s children will also have the condition.

What is Syringocystadenoma Papilliferum?

Syringocystadenoma papilliferum is a very rare, benign adnexal tumor that originates from the apocrine sweat glands. Herein, we report a 25-year-old male who presented with a 10-year history of an asymptomatic slowly growing skin lesion on his face.

What is Pilomatrixoma?

Pilomatricoma, also known as pilomatrixoma, is a type of noncancerous (benign) skin tumor associated with hair follicles. Hair follicles are specialized structures in the skin where hair growth occurs. Pilomatricomas occur most often on the head or neck, although they can also be found on the arms, torso, or legs.

What is an adnexal tumor?

A lump in tissue near the uterus, usually in the ovary or fallopian tube. Adnexal masses include ovarian cysts, ectopic (tubal) pregnancies, and benign (not cancer) or malignant (cancer) tumors.

Can a malignant eccrine spiradenoma be on the head?

Malignant eccrine spiradenoma is a type of tumor that develops from a sweat gland in the skin. It starts as a rapidly-growing bump on the head or abdomen, and may cause tenderness, redness, or an open wound. [1]

Where does the name spiradenoma come from?

They were first described in 1956 by Kersting and Helwig as a distinct form of sweat gland tumor ,which they called eccrine spiradenoma. In current practice, they are considered to originate from the hair follicle bulge, rather than the sweat gland.

How big is the spiradenoma on the upper trunk?

Spiradenoma presents as a skin-colored, blue, or pink nodule located most commonly on the upper trunk or extremities (Figure 1). The nodule is well demarcated and has a spongy or cystic feel. It is usually less than 1 cm in size; however, they can grow larger and may be painful or tender.

How is a spiradenoma different from a benign stroma?

Histologically, the malignant spiradenoma may be differentiated from its benign counterpart by the presence of cytologic atypia, loss of a well circumscribed architecture, necrosis, infiltration of strands into the stroma, and numerous mitoses. Multiple spiradenomas may be a sign of a familial spiradenoma syndrome or Brooke-Spiegler syndrome.