Is pravastatin a high intensity statin?
— High-intensity statin therapies are atorvastatin (40–80 mg) or rosuvastatin (Crestor; 20–40 mg). Moderate-intensity statin therapies include atorvastatin (10–20 mg), rosuvastatin (5–10 mg), simvastatin (20–40 mg), pravastatin (40–80 mg), and several others.
Do statins interfere with exercise?
Conclusion: Statins may increase the incidence of exercise-related muscle complaints and in some studies augment the exercise-induced rise in muscle enzymes, but statins do not consistently reduce muscle strength, endurance, overall exercise performance or physical activity.
Do statins affect running?
New research indicates the prescription medicine doesn’t impact distance or pace. Runners have little to fear from statin medications, according to an analysis of the huge National Runners Health Study and other new research.
Which statins are high intensity?
High-, Moderate-, and Low-Intensity Statin Therapy (Used in the RCTs Reviewed by the Expert Panel)*
| High intensity | Moderate intensity |
|---|---|
| Atorvastatin (Lipitor), 40† to 80 mg | Atorvastatin, 10 (20) mg |
| Rosuvastatin (Crestor), 20 (40) mg | Rosuvastatin, (5) 10 mg |
| Simvastatin (Zocor), 20 to 40 mg‡ | |
| Pravastatin (Pravachol), 40 (80) mg |
Who needs a high-intensity statin?
Four groups of patients are recommended for intense statin treatment: Adults with clinical ASCVD, which encompasses coronary artery disease, peripheral artery disease, transient ischemic attack or stroke. Adults age 40 to 75 with diabetes. Adults of any age with LDL above 190.
What are some side effects of pravastatin?
The more common side effects that can occur with use of pravastatin include:
- muscle pain.
- nausea.
- vomiting.
- diarrhea.
- headache.
- common cold.
Can you lift weights while taking statins?
Although high-dose statin therapy may increase the incidence of muscle complaints or cause slight rises in muscle enzymes, these drugs do not reduce muscle strength or endurance.
Can athletes take statins?
Although statins increase exercise muscle injury and may reduce exercise training response, they appear to be safe in athletes, a presenter said.
Do statins make it hard to build muscle?
What does high intensity statin mean?
Definitions: *High Intensity Statin Therapy–defined as dose expected to reduce LDL- C by greater than or equal to 50% and includes the following: (1,2) Atorvastatin 40-80mg everyday. Rosuvastatin 20-40mg everyday.
Who benefits from high intensity statin?
High-intensity statins are recommended for 2 categories of patients: those with ASCVD (secondary prevention) and high-risk patients without clinical ASCVD. Most patients with ASCVD are candidates for high-intensity statins, with a goal for low-density lipoprotein cholesterol reduction of 50% or greater.
When should I start taking high intensity statins?
While prior guidelines suggested high-intensity statins for patients with diabetes if their 10-year ASCVD risk is ≥7.5%, the current guidelines recommend initiating high-intensity statin for those with the presence of multiple risk factors to reduce LDL-C levels by ≥50%.
What are the characteristics of high intensity statins?
Baseline and procedure characteristics between the high‐intensity statin group (n=372) and the non‐high‐intensity statin group (n=1374) are presented in Table 1. The high‐intensity statin group had a higher prevalence of diabetes mellitus, current smoker, previous cerebrovascular accident event, and acute coronary syndrome on admission.
Which is the best statin to take for high LDL?
In patients who have suffered an AMI, an LDL-C reduction of at least 50% from baseline together with an LDL-C goal of <55 mg/dL (<1.4 mmol/L) are recommended (both goals need to be achieved). [1] [2] High-intensity statins such as atorvastatin 40-80 mg or rosuvastatin 20-40 mg usually result in an LDL-C reduction of around 50%.
When to add ezetimibe to a statin treatment?
LDL-C levels should be re-checked after 6-8 weeks. If patients fail to reach target levels, ezetimibe 10mg once daily should be added and is associated with improved outcomes. In patients with high LDL-C unlikely to reach goal with a statin alone, an statin-ezetimibe combination treatment should be considered upfront during index hospitalization.
How are statins used to treat vascular events?
Patients that experience a second vascular event within two years while taking maximum-tolerated statin therapy, an LDL-C goal of < 40mg/dL may be considered. By inhibiting the HMG-CoA-reductase activity in hepatocytes, statins reduce hepatic cholesterol synthesis, leading to lower intracellular cholesterol levels.