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Does methotrexate affect male fertility?

Methotrexate may cause an increased chance of infertility. Low sperm count has been seen in some males using methotrexate. Most of these males were using high doses of the medication, as well as other medications to treat cancer.

Does methotrexate reduce fertility?

Methotrexate and fertility The risk of infertility appears low even after high-dose MTX. One review reports a 97% conception rate in women 1 year or more after cessation of MTX treatment.

Do immunosuppressants affect male fertility?

It is known that immunosuppressive drugs can affect male sexual health and reproduction via multiple mechanisms: by altering reproductive hormone secretion and/or action, by disrupting spermatogenesis or sperm motility and by causing sexual dysfunction (Sasaki et al., 2011).

Does methotrexate affect sperm quality?

A transient adverse effect on sperm quality with low-dose MTX has been reported, but several other cases have not found harmful effects of MTX. MTX has not been measured in human sperm ejaculates; yet, the risk of a direct toxic effect on the fetus through MTX-contaminated seminal plasma seems negligible.

How long after methotrexate can I try to conceive?

Owing to concerns about MTX and its metabolites remaining in some organs and possibly affecting pregnancy or fetal development, manufacturers and several sources have arbitrarily recommended that women wait 3 to 6 months to become pregnant after stopping therapy.

Can immunosuppressants make you infertile?

Immunosuppressive drugs are used in the treatment of inflammatory and autoimmune diseases, as well as in transplantation. Frequently prescribed in young people, these treatments may have deleterious effects on fertility, pregnancy outcomes and the unborn child.

Does hydroxychloroquine affect male fertility?

This antimalarial drug is used either alone or in combination with other DMARDs in rheumatoid arthritis. It is also used to prevent flares in patients with SLE. Fertility and Conception. There are no reports of adverse effects of hydroxychloroquine on fertility.

Can I have a baby while taking methotrexate?

Methotrexate isn’t safe during pregnancy Using methotrexate while you’re pregnant could end your pregnancy or cause severe birth defects. These birth defects could affect the way your child looks, develops, or functions for the rest of their life.

What happens if my partner or I become pregnant while taking methotrexate?

Methotrexate, a common treatment for RA, can cause birth abnormalities if either partner takes the drug during conception or pregnancy. Women who become pregnant while taking methotrexate should stop taking methotrexate and contact a doctor as soon as possible.

Can methotrexate affect egg quality?

Methotrexate has previously been shown to have a negative effect on oocyte yield in repeat ART cycles performed within 180 days of methotrexate (3). In univariate regression sensitivity analyses, oocyte yield and time between repeat ART treatment was not correlated (P =0.19).

Does medication affect sperm quality?

Testosterone replacement therapy, long-term anabolic steroid use, cancer medications (chemotherapy), certain antifungal and antibiotic medications, some ulcer medications, and other medications can impair sperm production and decrease male fertility.

Does methotrexate affect fertility?

Methotrexate Pregnancy Warnings. This drug causes teratogenic effects, embryotoxicity, abortion, and fetal defects in humans. It has also been reported to cause impairment of fertility, oligospermia and menstrual dysfunction in humans, during and for a short period after cessation of therapy.

Does methotrexate adversely affect the heart?

In addition to being an effective treatment for rheumatoid arthritis, methotrexate reduces the risk of death from heart disease . This may be because it reduces inflammation, a risk factor for heart disease, and because it affects the cellular mechanisms that lead to the deposition of fat in arterial walls.

Does methotrexate cure arthritis?

Methotrexate is one of the most effective and widely used medications for treating inflammatory types of arthritis. It’s also one of the safest arthritis drugs, despite a common misconception among many patients that methotrexate is highly toxic.