Does heterogeneous mean cancer?
Cancer is a heterogeneous disease. Practically from the moment pathologists first looked at human cancers under the microscope, they saw that differing histologic appearances could define distinct subtypes of cancers from the same primary site of origin.
What is important about the gene BRCA1?
Normally, the BRCA1 and BRCA2 genes protect you from getting certain cancers. But some mutations in the BRCA1 and BRCA2 genes prevent them from working properly, so that if you inherit one of these mutations, you are more likely to get breast, ovarian, and other cancers.
What is SKOV3 cell line?
3; SKOV3; Skov3 and SKO3) is an ovarian cancer cell line derived from the ascites of a 64-year-old Caucasian female with an ovarian serous cystadenocarcinoma. The SK-OV-3 cell line is also hypodiploid, with a modal number of chromosomes of 43 (range 42-45), occurring in 63.3% of cells.
Is BRCA1 mutation dominant or recessive?
For example, mutations in the BRCA1 and BRCA2 genes are inherited in an autosomal dominant pattern , which means one copy of the altered gene in each cell is sufficient to increase a person’s chance of developing cancer.
What type of mutation is the BRCA1?
A BRCA mutation is a mutation in either of the BRCA1 and BRCA2 genes, which are tumour suppressor genes. Hundreds of different types of mutations in these genes have been identified, some of which have been determined to be harmful, while others have no proven impact.
What are heterogeneous diseases?
A heterogeneous medical condition or heterogeneous disease is a medical term referring to a medical condition with several etiologies (root causes), such as hepatitis or diabetes.
What causes mutations in BRCA1?
In the nucleus of many types of normal cells, the BRCA1 protein interacts with several other proteins to mend breaks in DNA. These breaks can be caused by natural and medical radiation or other environmental exposures, and they also occur when chromosomes exchange genetic material in preparation for cell division.
What is ovarian serous Cystadenocarcinoma?
Ovarian serous cystadenocarcinoma is the malignant form of ovarian serous tumor, the most common type of ovarian epithelial tumor. It is the most common type of ovarian malignancy.
What is a BRCA1 mutation?
A small percentage of people (about one in 400, or 0.25% of the population) carry mutated BRCA1 or BRCA2 genes. A BRCA mutation occurs when the DNA that makes up the gene becomes damaged in some way. When a BRCA gene is mutated, it may no longer be effective at repairing broken DNA and helping to prevent breast cancer.