What is anti SSA and anti SSB?
Anti‐SSA and ‐SSB antibodies are clinically important antinuclear antibody (ANA) in patients with systemic rheumatic diseases. These antibodies are found in Sjögren’s syndrome (SS), as well as other systemic autoimmune diseases (ADs), such as systemic lupus erythematosus (SLE), myositis, scleroderma, etc.
What does positive SSA and SSB mean?
Interpretation. A positive result for SSA (Ro) or SSB (La) antibodies is consistent with connective tissue disease, including Sjogren syndrome, lupus erythematosus (LE), or rheumatoid arthritis.
What does SSB antibody mean?
Anti-Sjögren’s syndrome type B (SSB) antibodies are one of the most common autoantibodies in the serum of SLE patients and also one of the earlier autoantibodies to be produced (11–13).
Does positive SSA mean lupus?
A positive result for SS-A/Ro antibodies is consistent with connective tissue disease, including Sjogren syndrome, lupus erythematosus (LE), or rheumatoid arthritis. A positive result for SS-A/Ro antibodies in a woman with LE prior to delivery indicates an increased risk of congenital heart block in the neonate.
What is the difference between SSA and SS-B?
Anti-Ro/SSA are the most prevalent specificity among many autoimmune diseases, such as systemic lupus erythematosus (SLE), SS/SLE overlap syndrome, subacute cutaneous LE (SCLE), neonatal lupus and primary biliary cirrhosis. In contrast, anti-La/SSB is more associated with Sjögren’s syndrome (SS).
Can you test positive for Sjogren’s and not have it?
False positives can occur in older people, after trauma, or in people with hepatitis C, lymphoma, or sarcoidosis11. Salivary gland biopsies are an important tool for the diagnosis of Sjögren’s in people with negative blood tests and no dry mouth or eye, but with other Sjögren’s-like symptoms.
What is the difference between SSA and SSB?
What does it mean if Sjogren’s anti SS A is high?
Elevated anti-SS-A antibodies and/or anti-SS-B antibodies indicate inflammatory connective tissue disease, especially Sjögren’s syndrome. Your healthcare provider might order these tests for you if there is a concern that you could have: Sjögren’s syndrome. Systemic lupus erythematosus (SLE)
What is Sjogren’s SSB?
SSB or La is composed of a 48-kDa protein combined with RNA species. SSB antibodies are found primarily in patients with Sjogren syndrome or SLE, where they occur with frequencies of approximately 60% and 15%, respectively. (1,2) SSB antibodies occur only infrequently in the absence of SSA antibodies.
How are anti Ro and anti La antibodies used in lupus?
Anti-Ro (SSA) and La (SSB) antibody determinations have become important serologic tests in the evaluation of lupus erythematosus and Sjögren’s syndrome patients. These antibodies appear to identify a group of lupus patients with prominent skin diseases.
Can a person with lupus have anti-nuclear antibodies?
They are also commonly found in people with lupus who have tested negative for anti-nuclear antibodies. Anti-Ro and anti-La can also be found in other rheumatic diseases, such as systemic sclerosis, rheumatoid arthritis, and polymyositis, and are present in low titers in about 15% of healthy individuals.
What kind of antibodies are used for Ro / SSA?
Anti-Ro/SSA and anti-La/SSB antibodies were originally described in 1961 as two precipitating antibodies reacting with antigens contained in extracts from salivary and lacrimal glands of patients with SS, termed SjD, and SjT, respectively [9].
What does absence of anti dsDNA mean for lupus?
[The absence of anti-dsDNA, however, does not exclude a diagnosis of lupus.] The presence of anti-dsDNA antibodies often suggests more serious lupus, such as lupus nephritis (kidney lupus). When the disease is active, especially in the kidneys, high amounts of anti-DNA antibodies are usually present.