What does a low IgG4 level mean?

Low serum IgG4 concentrations are insufficient to fight with complement activators such as IgG1 and IgG3 and fail to block the binding of antigen and harmful autoantibodies, thereby causing autoimmune diseases.

What causes low immunoglobulin?

Low levels of immunoglobulins mean your immune system isn’t working as well as it should. This can be caused by: Medicines that weaken your immune system, such as steroids. Diabetes complications.

What does it mean when your IgG is low?

An IgG deficiency is a health problem in which your body doesn’t make enough Immunoglobulin G (IgG). People with IgG deficiency are more likely to get infections. When your body feels it is under attack, it makes special proteins called immunoglobulins or antibodies. These antibodies are made by the plasma cells.

What are the causes of low IgG and IgM?

Low levels of the IgG antibody can also be caused by Waldenstrom’s macroglobulinemia, a rare blood cancer that is characterized by an overproduction of the IgM antibody and subsequent suppression of production of other types of antibodies, including IgG.

What does low IG mean?

Low IgG means something’s going on w/the immune system & is most often related to Primary Immune Deficiency Disorders. My son has the exact same thing- low IgA & low IgG but normal subsets (if those haven’t been tested, get them done b/c they give a better picture of what’s going on).

What is IgG deficiency definition?

IgG deficiency. IgG deficiency is a form of dysgammaglobulinemia where the proportional levels of the IgG isotype are reduced relative to other immunoglobulin isotypes. IgG deficiency is often found in children as transient hypogammaglobulinemia of infancy (THI), which may occur with or without additional decreases in IgA or IgM .

What is IgG blood test?

IgG Blood Test. This test measures the level of Immunoglobulin G (IgG) Antibodies in the blood. IgG are the smallest and most common type of antibody making up 75-80% of all antibodies in the body.