What is insular carcinoma of thyroid?
Abstract. Background: Insular carcinoma is a little-known thyroid cancer, characterized by the presence of well-defined nidi of small uniform cells with frequent areas of tumor necrosis and microfollicles with thyroglobulin. It was described by Carcangiu in 1984, but its prognosis is not yet clear.
What is a differentiated thyroid cancer?
Disease definition. A rare, slow-growing, epithelial thyroid carcinoma typically presenting as an asymptomatic thyroid mass and is classed as either papillary thyroid cancer (PTC), follicular thyroid cancer (FTC) or Hurthle cell thyroid cancer (HCTC).
What is follicular carcinoma of the thyroid?
Follicular thyroid cancer is a tumor of the follicular cells that are lined by cuboidal epithelial cells and have capsular and vascular invasive properties. Compared to follicular carcinoma, follicular adenoma is benign and occurs more commonly with a ratio estimated to be 5 to 1.
How fast does thyroid cancer grow?
This is because most thyroid cancers grow slowly and can come back even 10 to 20 years after treatment. Your cancer care team will tell you what tests you need and how often they should be done.
How does medullary carcinoma start?
Medullary thyroid cancer starts as a growth of abnormal cancer cells within the thyroid. These special cells are the parafollicular C cells. In the hereditary form of medullary thyroid cancer, the growth of these cells is due to a mutation in the RET gene which was inherited.
What does follicular pattern mean?
This term is often used to either designate thyroid parenchymal cells, which produce thyroid hormone and show expression of thyroglobulin or the growth pattern of a thyroid lesion—that is, follicle forming or follicular patterning (regarded as the functional unit of the thyroid in normal histology).
What is the first stage of thyroid cancer?
Stage I: This stage describes a small tumor (T1) with no spread to lymph nodes (N0) and no distant metastasis (M0). Stage II: This stage describes a larger localized tumor (T2 or T3) with no spread to lymph nodes (N0) and no metastasis (M0).
What are the characteristics of Insular art style?
Insular style is characterized by an interest in abstraction over figural ornament, an interest in linear pattern and rhythmic form over three-dimensional space and perspective, and, especially in manuscript illumination and metalwork, a love of colorful surfaces.
When was Insular art in the British Isles?
Insular art is a poorly defined area. Broadly speaking, it refers to the art of the British Isles and Ireland between, roughly, the years 600 and 900 CE.
Which is the prototypical type of insular carcinoma?
Prototypical type insular carcinoma: solid nests (may contain microfollicules) composed of small uniform cell with round hyperchromatic nuclei or convoluted nuclei, increased mitotic figures, necrosis ( Am J Surg Pathol 1984;8:655 )
Why is Insular art known as horror vacui?
It has also often been described as exhibiting horror vacui (literally “fear of open space”) because of its preference for all-over pattern.