What does carbonic anhydrase II do?
Carbonic anhydrase II (gene name CA2), is one of sixteen forms of human α carbonic anhydrases. Carbonic anhydrase catalyzes reversible hydration of carbon dioxide. Defects in this enzyme are associated with osteopetrosis and renal tubular acidosis.
Where is carbonic anhydrase 2 found?
proximal convoluted tubule
CARBONIC ANHYDRASE II DEFICIENCY This enzyme is present in cells of the proximal convoluted tubule and in the late distal nephron segments. It is involved in the process of H+ secretion in both locations.
What is the CA2 gene?
CA2 (Carbonic Anhydrase 2) is a Protein Coding gene. Diseases associated with CA2 include Osteopetrosis, Autosomal Recessive 3 and Renal Tubular Acidosis. Among its related pathways are Reversible hydration of carbon dioxide and Neuroscience.
What is human carbonic anhydrase II?
Human carbonic anhydrase II (HCA II) is a monomeric zinc-containing metalloenzyme that catalyzes the hydration of CO2 to form bicarbonate and a proton. The properties of the zinc have been extensively elucidated in catalysis, but less well studied as a contributor to structure and stability.
Where is carbonic anhydrase synthesized?
Carbonic anhydrase, enzyme found in red blood cells, gastric mucosa, pancreatic cells, and renal tubules that catalyzes the interconversion of carbon dioxide (CO2) and carbonic acid (H2CO3).
What is carbonic anhydrase?
Carbonic anhydrase is the enzyme that catalyzes the reversible reactions of carbon dioxide and water: CO 2 + H 2 O ↔ H + + HCO 3 − .
How does carbonic anhydrase affect blood pH?
Carbonic anhydrase, which is found within red blood cells, catalyzes a reaction converting CO2 and water into carbonic acid, which dissociates into protons, and bicarbonate ions. This process also maintains blood pH by controlling the amount of bicarbonate ions and protons dissolved in the blood.
What is alkalosis and acidosis?
Acidosis is a condition in which there is too much acid in the body fluids. It is the opposite of alkalosis (a condition in which there is too much base in the body fluids).
Which medication is a carbonic anhydrase inhibitor?
Examples of carbonic inhibitor medications currently available are acetazolamide, methazolamide, dorzolamide, brinzolamide, diclofenamide, ethoxzolamide, and zonisamide. Acetazolamide is available generically and under the brand name Diamox in 125, 200, and 500 mg tablets.