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Why is dexamethasone used with Velcade?

The addition of the proteasome inhibitor Velcade® (bortezomib) to the treatment combination Revlimid® (lenalidomide) plus dexamethasone improves survival when used as initial therapy in multiple myeloma among patients who do not intend to immediately undergo a stem cell transplant according to clinical trial results …

How do you administer bortezomib?

Bortezomib powder for solution for injection is administered via intravenous injection at the recommended dose of 1.3 mg/m2 body surface area twice weekly for two weeks on days 1, 4, 8, and 11, in a 21-day treatment cycle. This 3-week period is considered a treatment cycle.

When do you hold Velcade?

VELCADE may be administered either as a single agent or in combination with dexamethasone [see Clinical Studies (14.1)]. VELCADE therapy should be withheld at the onset of any Grade 3 nonhematological or Grade 4 hematological toxicities excluding neuropathy as discussed below [see Warnings and Precautions (5)].

Does dexamethasone give energy?

Dexamethasone can give people an increase in energy. They may also develop insomnia, or difficulty sleeping. Taking the medication in the morning may help to prevent this.

What is the role of dexamethasone in multiple myeloma?

Dexamethasone and the other steroids are useful in myeloma treatment because they can stop white blood cells from traveling to areas where cancerous myeloma cells are causing damage. This decreases the amount of swelling or inflammation in those areas and relieves associated pain and pressure.

How effective is Velcade for multiple myeloma?

According to an analysis of 23 studies that included a total of 1,051 patients, retreatment with Velcade-based therapy was effective and well tolerated in patients with relapsed/refractory myeloma. The overall response rate to Velcade retreatment across all studies was 39%.

What is a high M spike number?

Patients with a higher M spike (greater than 1.5 g/dL) or abnormal SFLC ratio are at a higher risk of disease progression.

Where is VELCADE injected?

How to use Velcade Vial. This medication is given by injection into a vein or under the skin by a health care professional. If you are receiving this medication under the skin, make sure that the injection site is changed each time to lessen injury under the skin.

Is VELCADE an injection or infusion?

VELCADE is available for intravenous injection or subcutaneous use.

What is another name for VELCADE?

Velcade is the trade name for Bortezomib. In some cases, health care professionals may use the trade name Velcade when referring to the generic drug name Bortezomib. Drug type: Bortezomib is a targeted therapy.

Can VELCADE be given at home?

GLASGOW — Patients with multiple myeloma are able to self-administer the proteasome inhibitor bortezomib (Velcade, Takedo Oncology) at home via subcutaneous injections, potentially improving quality of life and reducing healthcare resource utilisation, argue UK researchers.

How often do I need to take Velcade IV?

1.3 mg/m²/dose IV/SC twice weekly for 2 weeks (Days 1, 4, 8, and 11) followed by a 10-day rest period (Days 12-21) Therapy extending beyond 8 cycles: Standard schedule or maintenance schedule of once weekly for 4 weeks (Days 1, 8, 15, and 22) followed by a 13-day rest period (Days 23 to 35)

When to start Velcade in combination with prednisone?

Treatment may be started at the last tolerated dose [see Dosage and Administration (2.6)]. When administered intravenously, administer Velcade as a 3 to 5 second bolus intravenous injection. Velcade is administered in combination with oral melphalan and oral prednisone for 9, six-week treatment cycles as shown in Table 1.

Are there any side effects to taking Velcade?

Develop a rash of any type or have skin pain while receiving VELCADE. The side effects of VELCADE may impair your ability to drive or operate machinery. These are not all of the possible side effects with VELCADE. It is important to always contact your doctor if you experience any side effects while on VELCADE.

How is Velcade administered to a cancer patient?

VELCADE® (bortezomib) | Patient Information How is VELCADE administered? VELCADE is prescribed by a doctor experienced in the use of medications to treat cancer. It is administered by a healthcare professional as an injection into your vein (intravenously, or IV) or under your skin (subcutaneously, or SC).