What is the purpose of cross-presentation?
Antigen cross-presentation enables dendritic cells (DCs) to present extracellular antigens on major histocompatibility complex (MHC) I molecules, a process that plays an important role in the induction of immune responses against viruses and tumors and in the induction of peripheral tolerance.
What is cross-presentation and when is it likely to occur?
Cross presentation occurs when an antigen made outside the APC is internalized by endocytosis or phagocytosis, and instead of complexing with class II MHC, it is routed to a compartment containing class I MHC.
What is cross-presentation and why is it important quizlet?
Cross presentation permits the presentation of exogenous antigens, which are normally presented by MHC II, on the surface of uninfected dendritic cells by MHC I. This is important since some viruses or tumors do not normally infect APCs and could avoid immune detection.
Why is cross priming important?
The action of cross priming can bolster immunity against antigens that target intracellular peripheral tissues that are unable to be mediated by antibodies produced through B cells. Also, cross-priming avoids viral immune evasion strategies, such as suppression of antigen processing.
What does the MHC do?
The major histocompatibility complex and its functions. The function of MHC molecules is to bind peptide fragments derived from pathogens and display them on the cell surface for recognition by the appropriate T cells.
Is cross-priming the same as cross presentation?
Also, cross-priming avoids viral immune evasion strategies, such as suppression of antigen processing. Overall, cross presentation aids in facilitating an adaptive immune response against intracellular viruses and tumor cells.
Which is the best description of cross priming?
Cross-priming refers to the stimulation of antigen-specific CD8+ cytotoxic T lymphocytes (CTLs) by dendritic cell presenting an antigen acquired from the outside of the cell. Cross-priming is also called immunogenic cross-presentation.
What does priming mean in terms of Immunology?
Priming (immunology) The first contact of a T or B cell with its specific antigen is called priming and causes differentiation into effector T or B cells (cytotoxic, cytokine, antibody).
Why is cross priming important to the immune system?
Cross-priming is an important mechanism to activate cytotoxic T lymphocytes (CTLs) for immune defence against viruses and tumours.
How are DCS used in immunogenic cross priming?
Immunogenic cross-presentation (cross-priming) requires that DCs are licensed by T helper (T H) cells or natural killer T (NKT) cells, which renders them competent to programme CTLs for survival, effector function and memory cell generation.