What is Lysosomotropic amine?
Lysosomotropic amines can raise the acidic internal pH of the neutrophil lysosome and inhibit neutrophil function. Because pH and calcium regulation are intimately connected in various types of excitable cells, we studied the effects of several lysosomotropic weak bases on neutrophil calcium homeostasis.
What are Lysosomotropic drugs?
Many drugs approved for clinical medicine are lysosomotropic agents, characterized by promoting particular effects including cytoplasmic vacuolization, increase in number and size of lysosomes, inhibition of their enzymes and accumulation of undegraded material, leading mainly to phospholipidosis.
Is hydroxychloroquine a lysosomotropic agent?
The lysosomotropic agent, hydroxychloroquine, delivered in a biodegradable nanoparticle system, overcomes drug resistance of B-chronic lymphocytic leukemia cells in vitro. Cancer Biother Radiopharm.
What is the function of lysosomes?
Lysosomes are membrane-bound organelles with roles in processes involved in degrading and recycling cellular waste, cellular signalling and energy metabolism. Defects in genes encoding lysosomal proteins cause lysosomal storage disorders, in which enzyme replacement therapy has proved successful.
Is hydroxychloroquine a peg?
PLAQUENIL (hydroxychloroquine sulfate) tablets contain 200 mg hydroxychloroquine sulfate, equivalent to 155 mg base, and are for oral administration. Inactive Ingredients: Dibasic Calcium Phosphate, Hydroxypropyl Methylcellulose, Magnesium Stearate, Polyethylene glycol 400, Polysorbate 80, Starch, Titanium Dioxide.
Is hydroxychloroquine a steroid?
The Role of Hydroxychloroquine as a Steroid-sparing Agent in the Treatment of Immune Thrombocytopenia: A Review of the Literature.
Is chloroquine an immunosuppressant?
Chloroquine and its synthetic analogue, hydroxychloroquine also belong to the disease-modifying anti-rheumatic drug class because these drugs are immunosuppressive.
Is hydroxychloroquine a narcotic?
Hydroxychloroquine 200 mg is not a controlled substance under the Controlled Substances Act (CSA).
Where do lysosomotropic drugs accumulate in the body?
Lysosomotropic compounds or cationic amphiphilic drugs (CADs) belong to various pharmacological classes but share the same physicochemical properties that enable them to accumulate in acidic compartments of cells ( Fig. 1 ).
Which is an example of a lysosomotropic compound?
The mentioned drugs, chloroquine, hydroxychloroquine and azithromycin, highly accumulate in lysosomes/endosomes and their membranes, reaching about 100-fold higher intracellular than their extracellular concentration [ 7, 8 ], and thus belong to a group of lysosomotropic compounds (compounds that accumulate in lysosomes).
Are there any lysosomotropic drugs that are antiviral?
Lysosomotropic drugs show moderate antiviral effects even on coronaviruses. The antiviral activity is likely due to interference with endosomal pathway. 530 existing drugs were analysed for lysosomotropism, pharmacokinetics and toxicity.