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What is cross presentation in immunology?

From Wikipedia, the free encyclopedia. Cross-presentation is the ability of certain professional antigen-presenting cells (mostly dendritic cells) to take up, process and present extracellular antigens with MHC class I molecules to CD8 T cells (cytotoxic T cells).

What is cross presentation and when is it likely to occur?

Cross presentation occurs when an antigen made outside the APC is internalized by endocytosis or phagocytosis, and instead of complexing with class II MHC, it is routed to a compartment containing class I MHC.

What is cross presentation and why is it important quizlet?

Cross presentation permits the presentation of exogenous antigens, which are normally presented by MHC II, on the surface of uninfected dendritic cells by MHC I. This is important since some viruses or tumors do not normally infect APCs and could avoid immune detection.

What is cross priming in immunology?

“Cross-priming” refers to the activation of naive CD8+ T cells by antigen-presenting cells that have acquired nominal antigens from another cell.

What is the function of cross-presentation?

Antigen cross-presentation enables dendritic cells (DCs) to present extracellular antigens on major histocompatibility complex (MHC) I molecules, a process that plays an important role in the induction of immune responses against viruses and tumors and in the induction of peripheral tolerance.

What is the role of cross-presentation in CD8 T lymphocyte priming?

Cross-priming, the activation of naive CD8 T cells following DC-mediated cross-presentation—the process through which exogenous antigens are processed and presented onto MHC class I molecules—plays a major role in generating CD8 T cell immunity against cancers and viruses, upon vaccination, as well as in the induction …

What is cross presentation quizlet?

What is cross-presentation? ability for dendritic cells to activate both T helper cells and CTLs by presenting both MHC class I and II (it usually only presents MHC class II)

Which cytokine is known for its antiviral properties?

Once activated, PRRs initiate a series of signaling cascades that result in the production of the well-known antiviral cytokine, interferon (IFN).

What is the purpose of cross-presentation by dendritic cells?

The presentation of exogenous antigens on MHC class I molecules, known as cross-presentation, is essential for the initiation of CD8+ T cell responses. In vivo, cross-presentation is mainly carried out by specific dendritic cell (DC) subsets through an adaptation of their endocytic and phagocytic pathways.

What is the role of cross presentation in CD8 T lymphocyte priming?

What is the purpose of cross presentation by dendritic cells?

What is the function of cross presentation?