What is a nondepolarizing neuromuscular blocking agent?
Nondepolarizing neuromuscular blockers are competitive acetylcholine (ACh) antagonists that bind directly to nicotinic receptors on the postsynaptic membrane, thus blocking the binding of ACh so the motor endplate cannot depolarize.  This leads to muscle paralysis.
What is depolarizing agent?
Depolarizing agents Depolarizing agents produce their block by binding to and activating the ACh receptor, at first causing muscle contraction, then paralysis. They bind to the receptor and cause depolarization by opening channels just like acetylcholine does.
What is the difference between depolarizing and Nondepolarizing paralytics?
Thus, depolarizing muscle relaxants act as ACh receptor agonists, whereas nondepolarizing muscle relaxants function as competitive antagonists. This basic difference in mechanism of action explains their varying effects in certain disease states.
Which drugs is a Nondepolarizing neuromuscular blocker?
Neuromuscular Blockers, Nondepolarizing
How does D Tubocurarine work?
d-Tubocurarine acts as a non-depolarizing competitive antagonist at nicotinic acetylcholine receptors on the motor end plate of the neuromuscular junction, causing the relaxation of skeletal muscle.
Is succinylcholine a depolarizing muscle relaxant?
Succinylcholine is a depolarizing skeletal muscle relaxant. As does acetylcholine, it combines with the cholinergic receptors of the motor end plate to produce depolarization. This depolarization may be observed as fasciculations.
What are the side effects of neuromuscular blocking agents?
Acetylcholine plays a role in histamine release, muscarinic activation, vagolytic action, and norepinephrine release. As a result, side effects such as tachycardia and bradycardia, hypertension and hypotension, and bronchodilation and bronchospasm have been seen with their use (TABLE 1).
How do you reverse neuromuscular blocking agents?
AGENTS REVERSING NEUROMUSCULAR BLOCKADE  NMBAs may be reversed either by increasing the concentration of acetylcholine in the synaptic junction or aid the elimination of the drug or its metabolism.
Why is succinylcholine depolarizing?
Mechanism of Action A depolarizing neuromuscular blocking agent, succinylcholine adheres with post-synaptic cholinergic receptors of the motor endplate, inducing continuous disruption that results in transient fasciculations or involuntary muscle contractions and subsequent skeletal muscle paralysis.
How do depolarizing muscle relaxants work?
Depolarizing muscle relaxants acts as ACh receptor agonists. They bind to the ACh receptors and generate an action potential. However, because they are not metabolized by acetylcholinesterase, the binding of this drug to the receptor is prolonged resulting in an extended depolarization of the muscle end-plate.