What is a CTX blood test?
A test is available to help doctors and patients determine if patients taking bisphosphonates are at risk for osteonecrosis following dental treatment. This test is called the Collagen Type-1 C-Telopeptide (CTX)The serum CTX (C-Terminal Cross-Linking Telopeptide) measures the rate of bone turnover.
What is CTX in bone?
The C-terminal telopeptide (CTX), also known as carboxy-terminal collagen crosslinks, is the C-terminal telopeptide of fibrillar collagens such as collagen type I and type II. It is used as a biomarker in the serum to measure the rate of bone turnover.
What does high CTX mean?
increased bone resorption
Elevated levels of beta-C-terminal telopeptide (CTx) indicate increased bone resorption. Increased levels are associated with osteoporosis, osteopenia, Paget disease, hyperthyroidism, and hyperparathyroidism.
What is a normal CTX?
The female CTx reference interval was divided into four age groups. For women aged less than 30 years, the interval was 150-800 ng/L; 30-39 years, the interval was 100-700 ng/L; 40-49 years, the interval was 100-600 ng/L; and for women aged 50 years or more the interval was 100-700 ng/L.
What is CTX?
Overview. Cerebrotendinous xanthomatosis (CTX) is a rare condition that affects the body’s ability to metabolize fats known as cholesterols. Patients with CTX are unable to break down different forms of cholesterol, which build up in certain areas of the body.
What CTX means?
Corporate Trade Exchange
Corporate Trade Exchange (CTX) Definition.
Is CTX a fasting blood test?
Test Details A minimum of 12 hours fasting is required.
Is bone resorption good or bad?
This is a natural process that’s important for your health and wellbeing. But when resorption happens at a higher rate than it can be replaced, it can lead to a decrease in your bone mass and put you at higher risk for fractures and breakage.
Is high bone turnover good or bad?
An increase in bone turnover seen with aging and pathological states such as osteoporosis leads to deterioration of bone microarchitecture and thus contributes to an increase in the risk of fracture independent of low bone mineral density (BMD).
Is low bone turnover good?
Bone turnover markers increase in proportion to fracture risk, independent of bone mineral density (BMD). In general, turnover markers also tend to be higher in patients with low bone density. However, this correlation is not absolute in individuals and this application of the test is most useful in population studies.
Is fasting required for a CTX blood test?
Test Details A minimum of 12 hours fasting is required. Fasting morning collection 8-10 am (diurnal variations cause elevated levels at night). Dietary supplements containing biotin may interfere in assays and may skew results to be either falsely high or falsely low.
What is CTX treatment?
A drug used to treat many types of cancer and a certain type of kidney disease in children. CTX damages the cell’s DNA and may kill cancer cells. It may also lower the body’s immune response. CTX is a type of alkylating agent.
How is the CTX test related to bone turnover?
The CTX test measures for the presence and concentration of a crosslink peptide sequence of type I collagen, found, among other tissues, in bone. This specific peptide sequence relates to bone turnover because it is the portion that is cleaved by osteoclasts during bone resorption,…
What do the results of a CTX blood test mean?
CTx Blood Test Results Meaning. The CTx blood test is designed to measure the amount of bone materials that have degraded into a person’s bloodstream. By detecting the collagen of the bone, it is most commonly used to detect the presence of osteoporosis.
Can a bone fracture be detected by a CTX test?
Bone fractures can also happen at any place in the body. Instead of only measuring certain points in the body like other tests do, the CTx test evaluates the resorption rate of the entire skeleton so that an accurate diagnosis can be made.
What kind of blood test to check for bone breakdown?
Serum CTx bone breakdown test: CTx is a blood test used to monitor the rate of bone breakdown and the effectiveness of anti-resorptive natural or drug bone therapies. It tests for the C-terminal telopeptide of type I collagen, which is a peptide fragment derived from the carboxy terminal end of the bone protein matrix.