What are the contraindications of Demerol?
DEMEROL is contraindicated in patients with hypersensitivity to meperidine. Meperidine is contraindicated in patients who are receiving monoamine oxidase (MAO) inhibitors or those who have recently received such agents.
Why is Demerol contraindicated?
Meperidine is contraindicated in patients that are actively receiving or have been exposed during the past 14 days to monoamine oxidase inhibitors (MAOI) because of unpredictable severe, and occasionally fatal reactions such as coma, severe respiratory depression, hypotension, cyanosis, and acute narcotic overdose.
Why is Demerol contraindicated kids?
Nonetheless, it is has been recommended that the use of meperidine be avoided in children primarily due to the risk of seizures. There are case reports of adverse events associated with meperidine use in children. In neonates and infants specifically, a longer half-life and slower clearance was seen in one study.
What’s wrong with Demerol?
The problem with meperidine lies in how it’s metabolized in the liver, where some of the drug is converted into normeperidine, a potentially neurotoxic, nonopioid active metabolite. Normeperidine can cause altered mental status, nervousness, myoclonus, seizures, delirium, and psychosis.
What are the contraindications to the use of misoprostol?
Contraindications include pelvic infection or sepsis, hemodynamic instability or shock, allergy to misoprostol, known bleeding disorder, concurrent anticoagulant therapy, and confirmed or suspected ectopic or molar pregnancy.
Why is Demerol contraindicated with MAOI?
Concomitant use of DEMEROL Tablets and Oral Solution with Monoamine Oxidase Inhibitors (MAOIs) Concomitant use of DEMEROL Tablets or Oral Solution with monoamine oxidase inhibitors (MAOIs) can result in coma, severe respiratory depression, cyanosis, and hypotension.
Can kids have Demerol?
This drug is a strong pain drug that can put your child at risk for addiction, abuse, and misuse. Misuse or abuse of this drug can lead to overdose and death. Talk with your child’s doctor.
Can meperidine be given IV?
Meperidine injection comes as a solution (liquid) to inject subcutaneously (just under the skin), intramuscularly (into a muscle), or intravenously (into a vein). It is usually injected subcutaneously or intramuscularly once every 3 to 4 hours as needed.
When a drug is not to be used in a certain patient condition this is referred to as?
Unapproved use of an approved drug is often called “off-label” use. This term can mean that the drug is: Used for a disease or medical condition that it is not approved to treat, such as when a chemotherapy is approved to treat one type of cancer, but healthcare providers use it to treat a different type of cancer.
Are there any contraindications to taking Demerol tablets?
CONTRAINDICATIONS. DEMEROL Tablets and Oral Solution are contraindicated in patients with: Significant respiratory depression [see WARNINGS AND PRECAUTIONS] Acute or severe bronchial asthma in an unmonitored setting or in the absence of resuscitative equipment [see WARNINGS AND PRECAUTIONS]
Is it safe to take Demerol tablets with MAOIs?
Use of DEMEROL Tablets or Oral Solution with MAOIs within last 14 days is contraindicated [see CONTRAINDICATIONS, WARNINGS AND PRECAUTIONS, DRUG INTERACTIONS]. DEMEROL (meperidine hydrochloride, USP) Tablet and Oral Solution are opioid agonists.
Is it safe to take Demerol with meperidine?
CONTRAINDICATIONS DEMEROL is contraindicated in patients with hypersensitivity to meperidine. Meperidine is contraindicated in patients who are receiving monoamine oxidase (MAO) inhibitors or those who have recently received such agents.
What are the inactive ingredients in Demerol tablets?
The DEMEROL Oral Solution is a pleasant-tasting, nonalcoholic, banana-flavored solution containing 50 mg of meperidine hydrochloride, per 5 mL (10 mg/mL). The Inactive Ingredients in DEMEROL Tablets include: Calcium Sulfate, Dibasic Calcium Phosphate, Starch, Stearic Acid, and Talc. The Tablets are white, round and convex.