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What are metal binding drugs?

Chelating agents are usually organic compounds (a compound that contains carbon). Specific chelating agents bind iron, lead, or copper in the blood and can be used to treat excessively high levels of these metals. Chelating agents may also be used in the treatment of heavy metal poisoning.

How does cisplatin work?

Cisplatin binds to the N7 reactive center on purine residues and as such can cause deoxyribonucleic acid (DNA) damage in cancer cells, blocking cell division and resulting in apoptotic cell death. The 1,2-intrastrand cross-links of purine bases with cisplatin are the most notable among the changes in DNA.

Do lipid soluble drugs bind to plasma proteins?

Plasma Protein Binding It is the non-ionized lipid-soluble form of the drug that is free to act, and it is unbound drug, i.e., drug that’s not bound to plasma proteins, that is also free to diffuse through membranes and act.

Why are transition metals used in medicine?

Transition metal complexes have a long history of use as antibacterial and antiviral agents; for example, Zn is used to treat herpes, possibly by inhibiting the viral DNA polymerase. Early transition-metal (e.g., tungsten) polyoxoanions have been employed to treat AIDS patients.

What medications contain heavy metals?

These drugs supply sulfhydryl groups for the heavy metals to attach and, subsequently, may be eliminated from the body.

  • Dimercaprol (British Anti-Lewisite; BAL)
  • Edetate calcium disodium (Calcium Disodium Versenate)
  • Penicillamine (Cuprimine, Depen)
  • Succimer (Chemet)

What drug is given with cisplatin?

Droperidol 1 mg was given intramuscularly (IM) 15 minutes prior to beginning cisplatin. Repetitive doses of intravenous (IV) metoclopramide, 2 mg/kg in 75 ml 5% dextrose in water over 15 minutes was given 30 minutes prior to, and at 1 1/2, 4 1/2, and 7 1/2 hours after beginning cisplatin chemotherapy.

What is the most common side effect of cisplatin?

The following side effects are common (occurring in greater than 30%) for patients taking Cisplatin: Nausea and vomiting. Nausea may last up to 1 week after therapy. Anti-nausea medication is given before the infusion, and a prescription is also given for use after.

Is cisplatin a carcinogen?

Traditionally, cisplatin has not been regarded among chemotherapeutic drugs as a carcinogenic risk to humans because it is not a classical alkylating agent.

Do drugs need to be protein bound?

As a general rule, agents that are minimally protein bound penetrate tissue better than those that are highly bound, but they are excreted much faster. Among drugs that are less than 80-85 percent protein bound, differences appear to be of slight clinical importance.

Which metals are used in medicines?

These three metals are used in modern medicine:

  • Iron. Iron is one of the most vital minerals in our bodies, and medical applications are mined from iron ore.
  • Zinc. Zinc is a metal found in every tissue of the body.
  • Platinum.

What does protein binding do to a drug?

Protein binding can enhance or detract from a drug’s performance. As a general rule, agents that are minimally protein bound penetrate tissue better than those that are highly bound, but they are excreted much faster. Among drugs that are less than 80-85 percent protein bound, differences appear to … Protein binding: what does it mean? DICP.

What are the most common protein bound drugs?

1 List of Commonly Used, Highly Protein Bound Drugs. 2 Antimicrobials Anticoagulants Psychotropics. 3 Doxycycline Phenytoin Tetrahydrocannabinol. 4 Clindamycin Valproic acid Miscellaneous. 5 Nalidixic acid Hypoglycemics Diphenhydramine. 6 (more items)

What’s the difference between protein bound and minimal bound drugs?

As a general rule, agents that are minimally protein bound penetrate tissue better than those that are highly bound, but they are excreted much faster. Among drugs that are less than 80-85 percent protein bound, differences appear to be of slight clinical importance.

Are there any vitro studies of protein binding?

Studies that look at the impact of protein binding in a separate bacterial compartment, however, would more closely resemble the in vivo situation. Conclusions with respect to the impact of protein binding based on in vitro studies should therefore be viewed with the utmost caution.