How do you use tolvaptan?
Take this medication by mouth with or without food as directed by your doctor, usually once daily. You should not take this medication for longer than 30 days. To prevent losing too much body water (dehydration), always have water ready to drink while taking tolvaptan.
What is the mechanism of action of tolvaptan?
Mechanism of action and uses Tolvaptan is a competitive antagonist at vasopressin V2 receptors. Its major action is in the renal collecting ducts to reduce water reabsorption and produce aquaresis without sodium loss, thus increasing free water clearance and correcting dilutional hyponatraemia.
What are the side effects of tolvaptan?
Common side effects of Samsca include:
- increased thirst or urination,
- dry mouth,
- loss of appetite,
- constipation,
- weakness,
- fruity breath odor,
- drowsiness,
- dry skin,
How long does it take for tolvaptan to work?
The onset of effect is two to four hours after a dose is taken, and peak effects occur four to eight hours after administration. Taking tolvaptan with food does not appear to affect the drug’s bioavailability or its onset or duration of effect.
What is the purpose of tolvaptan?
Tolvaptan (Samsca) is used to treat hyponatremia (low levels of sodium in the blood) in people who have heart failure (condition in which the heart cannot pump enough blood to all parts of the body), syndrome of inappropriate antidiuretic hormone (SIADH; condition in which the body produces too much of a certain …
How does tolvaptan treat hyponatremia?
Tolvaptan is a breakthrough in the therapy of hyponatremia as it directly combats elevated AVP levels associated with the syndrome of inappropriate secretion of antidiuretic hormone, congestive heart failure, and cirrhosis of the liver.
What is the function of tolvaptan?
Does tolvaptan lower blood pressure?
Tolvaptan showed neither a significant reduction in the blood pressure nor the heart rate over the period of 5 days (p > 0.05). Patients in the placebo arm showed a significant drop in both systolic and diastolic BP at the end of 5 days (p < 0.01) without any change in heart rate (p = 0.07).
What does tolvaptan treat?
How do you increase sodium levels in your blood?
Intravenous (IV) fluids with a high-concentration of sodium, and/or diuretics to raise your blood sodium levels. Loop Diuretics – also known as “water pills” as they work to raise blood sodium levels, by making you urinate out extra fluid.
Does tolvaptan increase creatinine levels?
In this study, we demonstrated that tolvaptan produced significant diuretic effects and reduced body weight in CKD patients. The urine osmolality was also decreased significantly. There was a slight increase in serum creatinine level, but improvement for hyponatremia was observed.