How do you administer IV Foscarnet?
Method of administration: Foscarnet should be administered by the intravenous route only, either by a central venous line or in a peripheral vein. When peripheral veins are used, the solution of foscarnet 24 mg/ml must be diluted.
What are side effects of Foscarnet?
Foscarnet may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- itching, redness, pain, or swelling in the place where you received your injection.
- nausea.
- stomach pain.
- back pain.
- loss of appetite or weight.
- constipation.
- headache.
- vision changes.
What is Foscarnet used for?
Foscarnet is principally used for the treatment of ganciclovir-resistant cytomegalovirus (CMV) infections in patients with the acquired immunodeficiency syndrome (AIDS) or in transplant recipients.
Which laboratory study should be monitored while patient is taking Foscarnet?
FREQUENT MONITORING OF SERUM CREATININE, WITH DOSE ADJUSTMENT FOR CHANGES IN RENAL FUNCTION, AND ADEQUATE HYDRATION WITH ADMINISTRATION OF FOSCAVIR IS IMPERATIVE.
What is the generic name for foscavir?
Foscavir Injection, Phosphonoformic acid (foscarnet) dosing, indications, interactions, adverse effects, and more.
How do you administer cidofovir?
Cidofovir is administered via intravenous infusion. Do not administer intraocularly. Intravenous infusion: Dilute in 100 mL 0.9% Sodium Chloride for injection prior to administration to decrease incidence of nephrotoxicity.
How long does foscarnet take to work?
It is usually infused slowly over 1 to 2 hours using an infusion pump.
Does foscarnet cause hypocalcemia?
Foscarnet is a drug used to treat refractory cytomegalovirus and herpes infections in patients who are immunocompromised, and it complexes ionized calcium and, therefore, lowers ionized calcium concentrations, potentially causing symptomatic hypocalcemia.
Why is cidofovir given with probenecid?
In these studies, probenecid appeared to decrease kidney tissue drug levels and associated nephrotoxicity by acting as a competitive inhibitor of cidofovir uptake by the proximal tubular epithelial cells. Probenecid is currently used as a nephroprotectant during clinical therapy with intravenous cidofovir.
How long does Foscarnet take to work?
What is the treatment for CMV virus?
Ganciclovir (Cytovene) is the first antiviral medication approved for the treatment of CMV infection. Ganciclovir, given intravenously, is the drug of choice for the treatment of CMV infection. Side effects include fever, rash, diarrhea, anemia, and low white blood cell and platelet counts.
When is cidofovir contraindicated?
Cidofovir therapy is contraindicated in patients with baseline renal disease, renal impairment, or renal failure defined as a serum creatinine concentration > 1.5 mg/dl or calculated creatinine clearance <= 55 ml/min and in those who have >= 2+ proteinuria (urine protein >= 100 mg/dl).
How much Foscarnet is in a milliliter of Foscavir?
FOSCAVIR INJECTION is a sterile, isotonic aqueous solution for intravenous administration only. The solution is clear and colorless. Each milliliter of FOSCAVIR contains 24 mg of foscarnet sodium hexahydrate in Water for Injection, USP.
How is Foscavir administered in a central vein?
FOSCAVIR is administered by controlled intravenous infusion, either by using a central venous line or by using a peripheral vein. The rate of infusion must be no more than 1 mg/kg/minute.
How much dilantin to give in one infusion?
INFUSION The rate of intravenous Dilantin administration should not exceed 50 mg per minute in adults and 1-3 mg/kg/min (or 50 mg per minute, whichever is slower) in pediatric patients because of the risk of severe hypotension and cardiac arrhythmias. Careful cardiac monitoring is needed during and after administering intravenous Dilantin.
How much Foscavir should I give before an infusion?
It is recommended that 750– 1000 mL of normal saline or 5% dextrose solution should be given prior to the first infusion of FOSCAVIR to establish diuresis. With subsequent infusions, 750–1000 mL of hydration fluid should be given with 90–120 mg/kg of FOSCAVIR, and 500 mL with 40–60 mg/kg of FOSCAVIR.