How does dantrolene sodium work?
Dantrolene sodium, sold under the brand name Dantrium among others, is a postsynaptic muscle relaxant that lessens excitation-contraction coupling in muscle cells. It achieves this by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors.
What is dantrolene the antidote for?
The first volume provides an introduction to the series and reviews three antidotes: naloxone, a specific opioid antagonist used in the treatment of opiate poisoning; flumazenil, used to reverse the sedative, anti-convulsant and muscle-relaxant effects of benzodiazepines; and dantrolene sodium, used in the treatment of …
How does dantrolene reverse hyperthermia?
It is helpful to place an MH treatment poster in the operating room. Dantrolene is a hydantoin derivative that directly interferes with muscle contraction by inhibiting calcium ion release from the sarcoplasmic reticulum, possibly by binding to ryanodine receptor type 1 (RYR-1).
How do you administer dantrolene IV?
Dantrium Intravenous should be administered by continuous rapid intravenous push beginning at a minimum dose of 1 mg/kg, and continuing until symptoms subside or the maximum cumulative dose of 10 mg/kg has been reached. If the physiologic and metabolic abnormalities reappear, the regimen may be repeated.
How often should you take dantrolene?
Dantrolene comes as a capsule to take by mouth. When used to treat spasticity, it is usually taken once a day for 7 days and then increased gradually every 7 days to three to four times a day.
Does dantrolene cause hyperkalemia?
When used with calcium channel blockers (verapamil or diltiazem), dantrolene may produce life-threatening hyperkalemia and myocardial depression. Otherwise there does not appear to be significant negative interaction with other drugs.
Is dantrolene a calcium channel blocker?
Due to its ability to reduce intracellular calcium levels, dantrolene is a specific and effective agent in the treatment of malignant hyperthermia. Verapamil, a calcium channel blocker, has the ability to decrease calcium influx and can interact with dantrolene to produce hyperkalemia and myocardial depression.
Can dantrolene be given io?
Answer: No data exists on the effectiveness of any of the dantrolene products when administered via the intraosseous route.
How do you dilute dantrolene?
Each vial of dantrolene sodium for injection should be reconstituted by adding 60 mL of sterile water for injection USP (without a bacteriostatic agent), and the vial shaken for approximately 20 seconds or until the solution is clear.
What are the side effects of pentothal sodium?
SIDE EFFECTS Pentothal (thiopental sodium) Adverse reactions include respiratory depression, myocardial depression, cardiac arrhythmias, prolonged somnolenceand recovery, sneezing, coughing, bronchospasm, laryngospasm and shivering.
What kind of drug is thiopental sodium pentothal?
The drug is a yellowish, hygroscopic powder, stabilized with anhydrous sodium carbonate as a buffer (60 mg/g of thiopental sodium). Pentothal (Thiopental Sodium for Injection) is an ultrashort-acting depressant of the central nervous system that induces hypnosis and anesthesia, but not analgesia.
How is pentothal used as an anesthetic agent?
When Pentothal (Thiopental Sodium for Injection) is used as the sole anesthetic agent, the desired level of anesthesia can be maintained by injection of small repeated doses as needed or by using a continuous intravenous drip in a 0.2% or 0.4% concentration.
Which is the best way to administer pentothal sodium?
MAINTAIN PATENCY OF THE AIRWAY AT ALL TIMES. This drug should be administered only by persons qualified in the use of intravenous anesthetics. Avoid extravasation or intra-arterial injection. Observe aseptic precautions at all times in preparation and handling of Pentothal (Thiopental Sodium for Injection) solutions.